Metallomics: An integrated science for metals in biology and medicine
Identifieur interne : 001B37 ( Main/Exploration ); précédent : 001B36; suivant : 001B38Metallomics: An integrated science for metals in biology and medicine
Auteurs : Hongzhe Sun [République populaire de Chine, Hong Kong] ; Zhi-Fang Chai [République populaire de Chine]Source :
- Annual Reports Section "A" (Inorganic Chemistry) [ 0260-1818 ] ; 2010.
Abstract
Metallomics and metalloproteomics are an emerging scientific area focusing on the molecular mechanisms of metal-dependent life processes and the entirety of metal and metalloid species within a cell or tissue/organ. Metallomics is also a part of functional proteomics, complements metabonomics and structural geonomics of metalloproteins. This review summarizes the recent progress of metallomics with a focus on analytical techniques capable of high-throughput quantification, distribution, speciation, identification and structural characterisation. The applications of these advanced analytical methods in the identification of metallo-/phosphor-/seleno-proteins, probing of structure-function relationships of metalloproteins, and the study of metallodrugs will be selectively outlined.
Url:
DOI: 10.1039/b920672h
Affiliations:
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Rep. Prog. Chem., Sect. A: Inorg. Chem.</title><idno type="ISSN">0260-1818</idno><idno type="eISSN">1460-4760</idno><imprint><publisher>The Royal Society of Chemistry.</publisher><date type="published" when="2010">2010</date><biblScope unit="volume">106</biblScope><biblScope unit="issue">Advance Articles</biblScope><biblScope unit="page" from="20">20</biblScope><biblScope unit="page" to="38">38</biblScope></imprint><idno type="ISSN">0260-1818</idno></series><idno type="istex">D4384BCD16ED1712F49AEC10B7DA60B6B45B9524</idno><idno type="DOI">10.1039/b920672h</idno><idno type="ms-id">b920672h</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0260-1818</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Metallomics and metalloproteomics are an emerging scientific area focusing on the molecular mechanisms of metal-dependent life processes and the entirety of metal and metalloid species within a cell or tissue/organ. Metallomics is also a part of functional proteomics, complements metabonomics and structural geonomics of metalloproteins. This review summarizes the recent progress of metallomics with a focus on analytical techniques capable of high-throughput quantification, distribution, speciation, identification and structural characterisation. The applications of these advanced analytical methods in the identification of metallo-/phosphor-/seleno-proteins, probing of structure-function relationships of metalloproteins, and the study of metallodrugs will be selectively outlined.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Sun, Hongzhe" sort="Sun, Hongzhe" uniqKey="Sun H" first="Hongzhe" last="Sun">Hongzhe Sun</name></noRegion><name sortKey="Chai, Zhi Fang" sort="Chai, Zhi Fang" uniqKey="Chai Z" first="Zhi-Fang" last="Chai">Zhi-Fang Chai</name><name sortKey="Chai, Zhi Fang" sort="Chai, Zhi Fang" uniqKey="Chai Z" first="Zhi-Fang" last="Chai">Zhi-Fang Chai</name></country><country name="Hong Kong"><noRegion><name sortKey="Sun, Hongzhe" sort="Sun, Hongzhe" uniqKey="Sun H" first="Hongzhe" last="Sun">Hongzhe Sun</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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